Best Exosome Serums

Exosomes are tiny vesicles, around 30–150 nanometres, found naturally in plants and in your own skin. In skincare they're used to support your skin's natural processes and deliver visible glow.

Want the full breakdown of the science? Read our complete guide: What Are Exosomes?

Clinical backing. Look for brands that publish their study size and duration, not just a percentage. Our Exosome Glow Serum is backed by a 4-week clinical study of 26 people.*

Exosome source. Plant-derived exosomes offer strong stability and an excellent safety profile for cosmetic use. Ours are cica-derived — 3 million per bottle.

What else is in the formula. Exosomes work best alongside proven supporting ingredients. Look for hydrators and gentle resurfacing agents.

Texture and routine fit. A serum you'll actually use daily beats one that sits in a drawer. Lightweight formulas that layer well under moisturiser and SPF suit most routines, AM or PM.

Suitability. Exosome serums are generally well tolerated, including by sensitive skin, and don't carry the sun-sensitivity considerations of retinol or AHAs.

Clinically proven results

• 100% saw more glowing skin, clinically proven*
• Clinic worthy rejuvenated skin in 14 days*
• 6-in-1 skin rejuvenation: clinically proven to visibly improve radiance, hydration, tone, firmness, elasticity and texture*
• 55% reduction in visible signs of skin stress (redness, puffiness, visible irritation)***
• 63% increase in skin renewal activity in 8 hours*
• Proven to deliver up to 12-hours of hydration**
• Helps support natural collagen production

What that looks like day to day

• Skin that looks brighter and more rested
• A calmer-looking complexion, with less visible redness and puffiness
• Lasting comfort and hydration through the day**
• Smoother-looking texture and a more even-looking tone*

Exosomes vs Retinol

Exosomes suit those wanting visible glow and rejuvenation with a gentle routine fit, AM or PM, with no sun-sensitivity considerations. Retinol is the long-established choice for smoother, younger-looking skin, but can cause irritation and needs careful SPF use.
How to choose: exosomes if your skin is sensitive or you want a daytime-friendly option; retinol if you're targeting fine lines and your skin tolerates it. Many people use both on alternate evenings.

Exosomes vs Vitamin C

Exosomes are your glow and rejuvenation step. Vitamin C is your antioxidant and brightening step.
How to choose: use both — vitamin C in the morning, exosomes AM or PM.

Exosomes vs Peptides

Both support firmer, smoother-looking skin. Exosomes deliver broad 6-in-1 rejuvenation benefits*; peptides are typically used for more targeted concerns.
How to choose: exosomes for all-round rejuvenation; peptides to target one specific concern. They layer well together.

Step 1: When to apply

Apply to clean skin, AM or PM. Unlike retinol, exosome serums don't carry sun-sensitivity considerations, so they fit either end of your routine.

Step 2: How to apply

1. Cleanse thoroughly to remove makeup, SPF and impurities
2. Apply 2–3 drops to clean, dry skin
3. Gently pat and press in with your fingertips — don't rub or tug
4. Allow 2–3 minutes to absorb before your next product
5. Follow with moisturiser
6. Always finish your morning routine with SPF

Step 3: Building it into your routine

Week 1–2: use 3 times a week to see how your skin responds
Week 3–4: build to every other day if well tolerated
Week 5+: daily use

What to expect, and when

• 14 days: clinic worthy rejuvenated skin*
• 4 weeks: 100% saw more glowing skin, clinically proven*

Works well together

• Hyaluronic Acid — adds a hydration layer alongside your exosome step
• Niacinamide — supports the look of an even tone and a comfortable skin barrier
• Vitamin C — vitamin C in the morning, exosomes AM or PM
• Ceramides — support the skin barrier while your exosome serum delivers glow

Introduce gradually

• Retinol — use retinol 2–3 times a week and your exosome serum on alternate days
• AHAs/BHAs — leave 10–15 minutes between application
• High-strength actives — start slowly

Keep separate

• Benzoyl Peroxide — use at different times of day
• Very high pH products — can affect formula stability

Layering order

Cleanser → Toner (if used) → Exosome serum → Hydrating serum → Moisturiser → SPF (AM)

*4-week clinical study of 26 people

**Clinical study of 31 people

***In-vitro testing of Cica Exosomes showed a 55% reduction in pro-inflammatory markers and a 63% increase in markers associated with skin renewal after 8 hours.